Remote ischaemic conditioning (RIC) makes use of the idea that your body is incredibly resilient and adaptable. 

"Ischaemia" refers to the concept of blood flow being reduced to an area of your body. Prolonged periods of ischaemia can be harmful to the body, as this deprives cells of vital nutrients and metabolites obtained from the blood. However, the body is accustomed to working and adapting under pressure - so during brief, transient periods of ischaemia, the blood-deprived region of the body undergoes certain physiological changes to adapt in order to be more efficient with the limited nutrients it has access to.

RIC therefore utilises this natural physiological process. By inducing short periods of ischaemia using a blood pressure cuff, while also allowing for breaks to enable the body to recover and prevent any actual harm from occurring to cells, we can "condition" these tissues to become more adaptive, flexible, and energy-efficient. We believe that, over time, this could lead to a reduction in post-stroke fatigue.